Lazio and Juventus will be quickly looking to put behind them their European disappointment by achieving a positive result at the Stadio Olimpico on Monday.
After their derby exploits against Roma last week the Biancocelesti are missing key players because of suspension including Giuseppe Biava, Stefan Radu and Senad Lulic, while Abdoulay Konko, Andre Dias and Bruno Pereirinha are unlikely to be fit in time for the clash.
Ogenyi Onazi and Stefano Mauri return from the suspension that saw them sit out the 1-1 draw against Fenerbahce, which ultimately eliminated Vladimir Petkovic's men from the Europa League.
Meanwhile, for Juventus, Giorgio Chiellini, who was injured in Friday's training session, is out and Sebastian Giovinco is unavailable, too. Simone Pepe is out for the season.
Claudio Marchisio is doubtful, which means Paul Pogba is likely to come in and replace him. Other than that, Juve is at full strength.
Lazio looked as though it would be title contenders heading into 2013, but has managed just two wins from its last 11 Serie A games.
Miroslav Klose is the club's top goalscorer with 10 league goals, but the veteran Germany striker has yet to find the back of the net against Juve in six attempts.
The Biancocelesti have only won once in their last 10 encounters against Antonio Conte's men in all competitions, a 2-1 Coppa Italia win.
Juventus' last defeat on the road in Serie A came against Lazio's fiercest rivals Roma, where a solitary strike from Francesco Totti separated the two sides.
Mirko Vucinic (pictured, right) had a five-year stint at Roma and also played for Lecce. The Montenegrin has featured against the Biancocelesti 21 times, scoring seven goals in the process.
Juve has not been beaten at the Stadio Olimpico in the league in the previous seven meetings with the last two encounters finishing 1-0 to Juventus.