Lazio have failed to find the back of the net in three of their last four Serie A matches but have been in noticeably better goalscoring form in Europe, where they have scored seven goals in their previous three outings - two of which came against Stuttgart in the first leg of this Europa League round of 16 tie.
Midfielders Hernanes and Lorik Cana picked up yellow cards in the victory, however, and as a result will miss the return fixture through suspension.
Lazio manager Vladimir Petkovic will also be without midfielder Cristian Brocchi who has a fractured metatarsal, Antonio Rossi who has a pulled hamstring, as well as striker Miroslav Klose and right-back Abdoulay Konko, both of whom are recovering from serious knee injuries and not due back until next month.
Stuttgart meanwhile welcome striker Vedad Ibisevic back from suspension. The Bosnia-Herzegovina international will replace Manchester United loanee Federico Macheda, who started on his own up top for the first leg. Fellow forward Cacau remains sidelined after a cruciate ligament rupture.
Also missing are midfielders Alexandru Maxim and Mamadou Bah, who have nose and tibula fractures, respectively.
Lazio have dropped to sixth in Serie A after being as high as third earlier this season. They have won just one of their last eight matches in the league.
Striker Libor Kozak, a Czech Republic international, is the highest active goalscorer in the Europa League with seven goals.
Lazio have conceded just five goals in their last nine Europa League matches.
Stuttgart have won just one Bundesliga match in 2013 and are presently 14th in the division - still eight points clear of Augsburg and a relegation playoff.
Stuttgart have not managed more than two goals in a match in any competition since a December 8 win over Schalke.
With 20 goals in all competitions, Vedad Ibisevic is Stuttgart’s top goalscorer this season.