Clint Dempsey (calf) only has a small change of featuring for Spurs after missing the 3-2 win over West Ham on Monday, although Tom Huddlestone (knee) should be back to compete for a place in the hosts' starting XI.
Younes Kaboul (knee) should still be out for Andre Villas-Boas' side with no set return date yet, while Sandro (knee) is out for the season.
Bacary Sagna (knee) is expected to miss out for the Gunners, with youngster Carl Jenkinson set to replace him at right-back.
Abou Diaby (thigh) is 50/50 for the clash after coming off during the 1-0 win over Aston Villa on 23 February, while Kieran Gibbs (thigh) is definitely out after being forced off during the 2-2 draw with Liverpool on 30 January.
Tottenham have lost only one of their last seven Premier League home games against bitter rivals Arsenal.
Spurs have been in a winning position in both of their last two games against the Gunners, but have gone on to lose each game 5-2.
Gareth Bale is only the eighth different Tottenham player to score over 15 Premier League goals in a season.
Andre Villas-Boas' side have scored 11 goals from outside the area - more than any other top flight side this season.
Lionel Messi and Gareth Bale are the only players from Europe's big five leagues to score six league goals from outside the box this campaign.
Spurs had 13 shots on target against West Ham on Monday - only Chelsea (15 vs Aston Villa) have had more in a league game this season.
Arsenal have 13 points from the past five Premier League games - a total only equalled by league leaders Manchester United.
Olivier Giroud (pictured) has had 26 headed attempts at goal this season - more than any other player in the Premier League.
No side in the top five European Leagues has averaged fewer fouls per game than Spurs (9.7) or Arsenal (9.8) this season.