Juventus will have a golden chance to at least maintain their advantage at the top of the Serie A table when they meet Siena on Saturday.
The reigning champions (55 points) are currently four points clear in first position ahead of second-placed Napoli and should still find themselves at least four points clear of the pack after the weekend.
The league-leaders play host to relegation-threatened Siena at Juventus Stadium in what seemingly should be a routine win.
Exacerbating things for Siena is the fact that Juventus will be on the rebound after losing to Roma 1-0 last weekend.
Prior to that result, Antonio Conte's men had lost just one of their previous 10 league matches and will be keen to rejoin the winners' circle against lowly Siena.
Napoli will be aiming to keep in touch with Juventus when they travel to Stadio Friuli on Sunday to meet ninth-placed Udinese.
Walter Mazzarri's side have not been in the greatest of form recently, failing to win any of their last four Serie A matches, and it will prove to be a tough ask to overturn their indifferent form this weekend given Udinese have only lost once at home all season.
At the other end of the table, 19th-placed Pescara's attempt to get closer to safety faces a major hurdle when they travel to top-four outfit Lazio on Sunday while bottom-placed Palermo - six points adrift of security - have a much easier task when they take on Genoa (17th) on Friday.
In other fixtures, Sampdoria host Chievo Verona, Roma travel to Atalanta and Bologna do battle with Fiorentina.
Elsewhere, Cagliari lock horns with Torino, Parma take on Catania and Inter tackle AC Milan in their highly-anticipated derby at the San Siro on Saturday.