Genoa will be out to try and ensure their Serie A status when they face an Inter side who can no longer quality for Europe on Sunday.
Davide Ballardini's side sit four points clear of Palermo, who occupy the final spot in the bottom three, following their goalless draw with Torino on Wednesday.
They welcome an Inter side to the Stadio Luigi Ferraris whose hopes of competing in next season's UEFA Europa League were dashed by their 3-1 home defeat to Lazio at San Siro on Wednesday.
Andrea Stramaccioni's men now have little left to play for in their final two games and Genoa will be hopeful that the visitors are low on motivation as they aim to better the 1-1 draw they earned in Milan back in December.
Esteban Cambiasso scored a late leveller to hand Inter a point on that day, cancelling out Ciro Immobile's second-half strike.
Neither Immobile or Genoa have been prolific this term, with Ballardini's troops netting a mere 38 goals so far. Marco Borriello has contributed 12 of those, and the former Milan man will undoubtedly be the centre of attention for an Inter defence which is the fourth best in the division.
Genoa have no new injury problems following their midweek exertions but long-term absentees Marco Rossi, Ruben Olivera and Damiano Ferronetti remain on the sidelines. By contrast Inter's injury list is considerably lengthy, with 12 first-team players including the likes of top scorer Rodrigo Palacio, strikers Antonio Cassano and Diego Milito and veteran Javier Zanetti all unavailable.
Still Stramaccioni will be eager for his charges to end a disappointing campaign on a high and, although Inter have lost five of their last six outings, with Ricardo Alvarez and Fredy Guarin playing a key role in their attack, they do possess the quality to break down a Genoa outfit that has shipped plenty of goals in a troubled season.
Genoa can still lose and assure their place in the top flight if Palermo fall to defeat at Fiorentina, however nerves are likely to be high among the home crowd and victory in the final home game would be a very satisfactory way to guarantee their Serie A future.