Manchester United v Norwich City - 15:00
Manchester United's top scorer Robin van Persie has shaken off a hip injury and will be fit. Defender Phil Jones will not be available for Saturday's league game because of an ankle injury. Norwich will be without midfielder Alex Tettey, who is out with a knee injury, with on-loan Sporting Kansas City forward Kei Kamara pushing for a place in the starting XI.
Everton v Reading - 15:00
Marouane Fellaini is expected to recover from injury, but forward Victor Anichebe is a doubt for Everton and will have a late fitness test. Pavel Pogrebnyak will be absent for Reading with the striker suspended for the next three games, with veteran forward Jason Roberts having injured his hip.
Southampton v QPR - 15:00
There remain fitness doubts over left-back Luke Shaw, who will have a late test with Danny Fox on standby if he fails to make the clash. Guly Do Prado is also a doubt with a knee injury. Harry Redknapp is hopeful that Esteban Granero and Bobby Zamora will have both recovered from knocks in time to play, with Fabio available once more at full-back.
Stoke City v West Ham - 15:00
Stoke will be without the suspended Robert Huth with either Marc Wilson or Geoff Cameron set to move across from full-back. West Ham captain Kevin Nolan is sidelined with a broken toe, while fellow midfielder Mark Noble is doubtful with an arm problem.
Sunderland v Fulham - 15:00
Midfielder Lee Cattermole has been ruled out with a knee injury for Sunderland, while Danny Rose is unavailable with a hamstring injury, leaving Jack Colback to cover at left back. Fulham's Simon Davies could play his first game in almost a year after finally overcoming a knee injury, but Mahamadou Diarra has been ruled out.
Swansea City v Newcastle United - 15:00
Michael Laudrup is set to return Ki Sung-yueng to his regular midfield role with either Kyle Bartley or Garry Monk to partner Ashley Williams at the back. Newcastle could be without captain Fabricio Coloccini, who is struggling with a back injury; January signing Mapou Yanga-Mbiwa could take over at the back.
Chelsea v West Brom - 15:00
Gary Cahill and Cesar Azpilicueta are both doubts due to illness and a thigh strain, respectively. Juan Mata, Frank Lampard, Ashley Cole and demba Ba are all set to be recalled. West Brom could be without two frontline strikers with on-loan Romelu Lukaku ineligible to face his parent club, while Shane Long is a doubt with an ankle injury.
Wigan v Liverpool - 17:30
Wigan defender Antolin Alcaraz could return to the starting line-up after a six-month lay-off with a groin injury. Daniel Sturridge will be assessed just before kick-off after aggravating a thigh injury, while defender Martin Skrtel is back in contention following a thigh strain.
Tottenham Hotspur v Arsenal - 16:00
Arsenal will be without defender Bacary Sagna (knee) for the north London derby. Midfielder Abou Diaby is rated as 50/50 with a calf problem. Clint Dempsey, Jermain Defoe and Tom Huddlestone all remain doubts for the clash, so Gareth Bale could retain his central berth behind Emmanuel Adebayor.
Aston Villa v Manchester City - 20:00
Ron Vlaar looks set to return for Aston Villa, but Nathan Baker will step in if he fails to pass a late fitness test. Chris Herd is also available having shaken off an injury. Maicon has been ruled out for a month after knee surgery, while Gareth Barry and Vincent Kompany both remain doubtful.