Venezuela's dreams of reaching the 2014 World Cup remain intact but they will need a win over Bolivia to keep up the pressure on Chile.
Cesar Farias' side currently occupy fifth place in the CONMEBOL group, trailing Chile in the fourth and final automatic qualification spot by virtue of goal difference with five games remaining.
And, though securing a place in the top five will see Venezuela reach the play-offs, they will be keen to avoid that lottery by grabbing fourth spot.
If they are to do so they will desperately need to rediscover their form. They have won just twice in their last five matches, and are the second lowest scorers in the group - with only bottom-of-the-table Paraguay having scored fewer.
However, they do come into the meeting with Bolivia on the back of a morale-boosting win over third-placed Colombia in March.
Things are not looking so good for their opponents, as they bid to secure a fourth World Cup finals appearance.
Bolivia sit just one place above the bottom of the table, though their hopes at home are boosted by the peculiar nature of the venue.
The Estadio Hernando Siles is the highest national football stadium in the world at 11,942 feet above sea level, with the thin air at altitude often posing problems for visiting teams.
Despite that fact, Venezuela have come away with victories from their last two trips to Bolivia and have won six of their last 10 clashes with Xabier Azkargorta's side.
Bolivia have won just once in their last five competitive matches - a 4-1 victory against Uruguay in October - and come into the game on the back of a 5-0 defeat to Colombia in March.
Carlos Saucedo, who scored a hat trick against Uruguay, is likely to be his side's biggest threat