Lyon midfielder Clement Grenier has been called up to the France national side as a replacement for Samir Nasri.
Nasri had been due to make his return to the national squad after a ban following Nasri's behaviour at Euro 2012.
The Manchester City midfielder swore at journalists during the tournament and was banned for three games with manager Didier Deschamps opting not to recall him once it had been served.
But fitness issues have forced Nasri to be pulled out with Grenier, who has been targeted by Arsenal, given the chance to impress in his place,
The development will come as a disappointment for Nasri, who told L'Equipe he was "very happy" to be back in the national side and wanted to show an improvement in his behaviour.
"I come into the squad with the desire to show that I can help this team and I’m not, how some people think, the idiot that makes a mess in the group," he added.
However, the French Football Federation confirmed Nasri has withdrawn due to "doubts over his health".
"Because of doubts on Samir Nasri's health after Manchester City's two games in the United States, Didier Deschamps has called up Clement Grenier," an FFF statement read.
Deschamps has also lost Gael Clichy, with the injured Manchester City defender replaced by Bordeaux's Benoit Tremoulinas.