Alex Ferguson will take charge of Manchester United for the last time at Old Trafford when Swansea City are the visitors on Sunday.
The 71-year-old announced on Wednesday that he will step down as manager at the end of the season, with David Moyes coming in to replace him in July, when his contract at Everton expires.
Ferguson has won 38 trophies during over 26 years in charge of United, including this season’s Premier League trophy - an achievement which the club will certainly honour this weekend.
He said: "The decision to retire is one that I have thought a great deal about. It is the right time. It was important to me to leave an organisation in the strongest possible shape and I believe I have done so.
"The quality of this league winning squad, and the balance of ages within it, bodes well for continued success at the highest level."
United will want to end the season and Ferguson’s reign on a high, especially after their 1-1 draw at Arsenal and 1-0 defeat at home to Chelsea last Sunday.
Rafael da Silva is suspended until the second game of next season after he was shown a straight red card for kicking out at fellow Brazilian David Luiz in the defeat to Rafael Benitez's side.
Danny Welbeck is not expected to feature against Swansea due to a knee problem, while Ashley Young has been ruled out for the rest of the campaign with an ankle injury.
Swansea have the unenviable task of facing United on such a landmark occasion, but go into the match on the back of a 3-2 win at relegation-threatened Wigan.
Michael Laudrup's side came from behind twice on Tuesday before Dwight Tiendalli snatched the winner in the 76th minute to damage Wigan’s hopes of survival.
First-choice goalkeeper Michel Vorm clashed heads with team-mate Ben Davies five minutes from time and had to be carried off on a stretcher.
However, the Netherlands international may be fit to start against United as Laudrup eased concerns about the injury following the game.
The Swansea boss said: "He seems okay. He was a little dizzy but knows what happened.
"I think we'll have to wait to see if he's 100 percent."
Laudrup is likely to be without talismanic attacker Michu for the rest of the season due to a hamstring injury, while Chico Flores (arm) and Ki Sung-Yueng (dead leg) will face late fitness tests ahead of the clash.