Juventus can take a step closer to back-to-back Serie A titles when they take on Napoli in a top-of-the-table clash on Friday night.
The leading two teams in Italy's top flight will meet at Napoli's Stadio San Paolo with the home side desperately needing a victory to stay in touch with Juventus.
The league leaders are six points ahead of Napoli and would almost have one hand on the Serie A championship if they win at Stadio San Paolo, although Juventus have not won there since 2000.
But in a bonus for Juventus, Napoli enter Friday's clash without a victory in five games across all competitions.
In a big weekend in Serie A, fourth-placed Milan will host Lazio, who sit third, while Inter Milan (fifth) travel to Catania (seventh).
Lazio moved above Milan last week with a 2-0 victory over Pescara, as Inter drew with their city rivals.
Milan can retake third spot with victory on Saturday but if they lose and Inter win, the latter will move into fourth.
In the other match on Saturday, Torino will host Palermo.
Apart from Catania versus Inter, the pick of Sunday's games will be Sampdoria versus Parma in Genoa.
Sampdoria and Parma are level on 32 points in the middle of the Serie A table with the former unbeaten in five games, while the latter are winless in seven.
In other games, Siena will host Atalanta, Genoa head to the Italian capital to take on Roma, Fiorentina will welcome Chievo to Florence, Bologna take on Cagliari and Pescara face Udinese.